Nieuwe studie van Lombardi en Mikovits gepubliceerd!
Geplaatst: 13 mei 2011, 21:35
Bron: http://www.prohealth.com/library/showar ... ibid=16156
Als dit waar is, hebben we misschien wel een biomarker te pakken voor XMRV positieve patiënten. 93% specificiteit en 96% sensitiviteit is zeeer hoog, helemaal voor deze aandoening.ProHealth.com
by VC Lombardi, JA Mikovits, et al.
May 13, 2011
Article Title
Xenotropic Murine Leukemia Virus-related Virus-associated Chronic Fatigue Syndrome Reveals a Distinct Inflammatory Signature – Source: In Vivo, 25:307-314, 2011
By Vincent C Lombardi, Judith A Mikovits, et al.
[Note: The full text pdf of this forthcoming article by Whittemore-Peterson/U of Nevada researchers is freely accessible online at www.megaupload.com/?d=V980UCHY. If you are not a member of this web hosting service, you will need to wait about 40 seconds to download using a ‘regular download’ button.]
Abstract
Background: The recent identification of xenotropic murine leukemia virus-related virus (XMRV) in the blood of patients with chronic fatigue syndrome (CFS) establishes that a retrovirus may play a role in the pathology in this disease.
Knowledge of the immune response might lead to a better understanding of the role XMRV plays in this syndrome. Our objective was to investigate the cytokine and chemokine response in XMRV-associated CFS.
Materials and Methods: Using Luminex multi-analyte profiling technology, we measured cytokine and chemokine values in the plasma of XMRV-infected CFS patients and compared these data to those of healthy controls. Analysis was performed using the Gene Expression Pattern Analysis Suite and the Random Forest tree classification algorithm.
Results: This study identifies a signature of 10 cytokines and chemokines which correctly identifies XMRV/CFS patients with 93% specificity and 96% sensitivity.
Conclusion: These data show, for the first time, an immunological pattern associated with XMRV/CFS.
Source: In Vivo, 25;307-314 (2011). Lombardi VC, Hagen KS, Hunter KW, Diamond JW, Smith-Gagen J, Yang W, Mikovits JA. Whittemore Peterson Institute, University of Nevada; Triad Medical Center; Nevada Center for Health Statistics and Informatics, University of Nevada; University of Nevada Reno, Department of Microbiology and Immunology Applied Research Facility, Reno, Nevada, USA. [Email Dr. Vincent C Lobardi, WPI, U of Nevada – vclombardi@gmail.com]