XMRV in UK
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- zonaanbidster
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XMRV in UK
Posted Oct 21 2010 4:49am UK XMRV Study
WPI started a study in March 2010 to look for HMRV (Human MLV Related Viruses - both X and P) in UK ME/CFS patients.
The study included 50 patients with ME who met the Canadian Consensus Critera, 50% male and 50% female, along with 50 controls.
It was a blind study.
The 100 samples were tested blindly by two labs who had never worked with MRV or mice (to ensure there was no possibility of contamination).
The labs first tested plasma and 48% of the ME plasma samples were positive for XMRV (all were also tested for mouse DNA and were negative).
Other samples were detectable only after culturing (some sort of special sample preparation).
In some samples, only the virus was detectable; on others, only the antibodies were detectable.
Multiple testing methods were necessary in order to find all of the XMRV positive samples.
In all, 80% of the ME patients in the study were positive for XMRV.
4% of the controls were also positive for XMRV (in line with the original WPI study).
Dr. Mikovitz emphasized that the XMRV was very difficult to find.
They have learned that subtle differences in storage, handling, and testing make a big difference and that multiple methods must be used to find it all.
The above was from Learning to Live with CFS blog here
Read her full post at the above link.
WPI started a study in March 2010 to look for HMRV (Human MLV Related Viruses - both X and P) in UK ME/CFS patients.
The study included 50 patients with ME who met the Canadian Consensus Critera, 50% male and 50% female, along with 50 controls.
It was a blind study.
The 100 samples were tested blindly by two labs who had never worked with MRV or mice (to ensure there was no possibility of contamination).
The labs first tested plasma and 48% of the ME plasma samples were positive for XMRV (all were also tested for mouse DNA and were negative).
Other samples were detectable only after culturing (some sort of special sample preparation).
In some samples, only the virus was detectable; on others, only the antibodies were detectable.
Multiple testing methods were necessary in order to find all of the XMRV positive samples.
In all, 80% of the ME patients in the study were positive for XMRV.
4% of the controls were also positive for XMRV (in line with the original WPI study).
Dr. Mikovitz emphasized that the XMRV was very difficult to find.
They have learned that subtle differences in storage, handling, and testing make a big difference and that multiple methods must be used to find it all.
The above was from Learning to Live with CFS blog here
Read her full post at the above link.
- Zuiderzon
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Op XMRV workshop voorgesteldparadox schreef:Hallo Zuiderzon, in welk tijdschrift is het artikel gepubliceerd? Ik kan het niet vinden op Pubmed en wil het graag lezen.
abstract beschikbaar in
http://regist2.virology-education.com/a ... 2010_8.pdf
denk niet dat het artikel al gepubliceerd is in een tijdschrift
Hoop doet leven!
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- verlorengezondheidman
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- Lid geworden op: 02 aug 2008, 17:24
@Zuiderzon,
Het valt mij op dat zelfs ME-patienten onder de strenge Canadese criteria geen 100% score halen qua XMRV/MLV besmetting, in dit geval 80%, is het denkbaar dat zelfs deze categorie vroeg of laat opgesplitst zal gaan worden, ik neem aan dat een ME-patient zonder retrovirus een andere behandeling aangeboden zal krijgen als een ME-patient met XMRV/MLV-retrovirus
Het valt mij op dat zelfs ME-patienten onder de strenge Canadese criteria geen 100% score halen qua XMRV/MLV besmetting, in dit geval 80%, is het denkbaar dat zelfs deze categorie vroeg of laat opgesplitst zal gaan worden, ik neem aan dat een ME-patient zonder retrovirus een andere behandeling aangeboden zal krijgen als een ME-patient met XMRV/MLV-retrovirus
Een zoönose is een infectieziekte die kan worden overgedragen van dieren op mensen.
http://www.youtube.com/watch?v=wVQy9-cyL98
LyME en co's INFO-topic!
http://www.me-gids.net/index.php?name=P ... ht=#218551
http://www.youtube.com/watch?v=wVQy9-cyL98
LyME en co's INFO-topic!
http://www.me-gids.net/index.php?name=P ... ht=#218551