Authors: Prachi Sharma1, @ (psharm9@emory.edu)
Kenneth A. Rogers1, (kroger3@emory.edu)
Suganthi Suppiah2 (ssuppi2@emory.edu)
Ross J. Molinaro2 (rjmolin@emory.edu)
Nattawat Onlamoon2,3 (onattawat@hotmail.com)
John Hackett Jr.4 (John.Hackett@abbott.com)
Gerald Schochetman4 (gerald.schochetman.abbott.com)
Eric A. Klein 5 (kleine@ccf.org)
Robert H Silverman6 (silver@ccf.org)
François Villinger1,2 (fvillin@emory.edu)
Abstract
Although XMRV dissemination in humans is a matter of debate, the prostate of select patients seem to harbor XMRV, which raises questions about its potential route of transmission. We established a model of infection in rhesus macaques inoculated with XMRV. In spite of the intravenous inoculation, all infected macaques exhibited readily detectable XMRV signal in the reproductive tract of all 4 males and 1 female during both acute and chronic infection stages. XMRV showed explosive growth in the acini of prostate during acute but not chronic infection. In seminal vesicles, epididymis and testes, XMRV protein production was detected throughout infection in interstitial or epithelial cells. In the female monkey, epithelial cells in the cervix and vagina were also positive for XMRV gag. The ready detection of XMRV in the reproductive tract of male and female macaques infected intravenously, suggests the potential for sexual transmission for XMRV.
http://niceguidelines.files.wordpress.c ... -route.pdf
Eindelijk weer een paper die openlijk de contaminatiediscussie aan de kaak stelt. Helaas niet zo'n goed nieuws voor degenen die XMRV positief zijn en die het nog niet goed beseften... Sexueel overdraagbaar dus. Gelukkig wordt niet iedereen er ziek van. Denk aan de 6% XMRV+ gezonde proefpersonen. Ik geloof dat maar 0,2% daarvan ME ontwikkeld. Lucky ME
