LDN (Low Dose Naltrexone)

[marlène]

Low Dose Naltrexone (LDN) wordt nu ook vermeld op de lijst van "basics" van www.hfme.com - vroeger bekend onder de naam ahummingbirdsguide.com als immuunstimulerend middel.

Low-dose naltrexone strengthens the immune system and may improve cognitive function. Dosage is 3 - 4.5 mg taken before bed. Toxicity is not a concern. Well tolerated by most M.E. patients if the dose is raised very slowly, although some minor symptoms/side-effects such as headaches may occur in the first few weeks. Requires a doctor‘s script. Note that this drug should never be taken in combination with any drugs which are opiates (eg. codeine, Tramal/Tramadol etc.)

Bron: http://www.hfme.org/PDF/Treating_ME_The_Basics.pdf

[greta]

Nieuw in mijn mailbox via de LDN yahoogroup:

I've been on LDN since March 3, 2010 for my FM & CFS. LDN has been a miracle for me. I am off all other medications. I was in a wheel chair and as of March 30th I am walking. I no longer have FM symptoms but I do still suffer from CFS. I also lost 35 lbs. in 30 days and believe me it was all done in the healthiest way possible. I have gotten my health back, my legs back and I am now a size 2 from a size 14. I can only thank GOD for giving me the strength to keep looking for the right Doctor.

I have no side effects from LDN. Has anyone experienced the same as I have?

[greta]

En nog 1 van de LDN yahoogroup;


I have had SPMS for 15 years mainly affecting the left side of the body with the leg totally rigid. I also have RLS & wear a splint because of dropped foot.

After taking LDN for 3 weeks the first symptom to improve was the left leg which became flexible ( for the first time in years) in the middle of the night. Over the next few weeks later the flexibility in the leg continued to improve & extend into the day in that it could bend down enough for me to kneel and mobility is much improved.

I live in a house on the side of a hill with five half levels so I climb lots of stairs. I would have had to get a lift as the right knee was complaining. Now I can bounce the left leg so stairs are not so difficult BUT I cannot lift the leg. Not yet. There is no improvement in the foot but I think the splint weakens it.

LDN has given me back my smell & taste, my voice, better balance, better mobility, no more sinus, stopped choking. I have not given up on the leg yet.

Trish

[greta]

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Van de LDN yahoogroup:

To those who have complained/commented that they develop cold and/or flu symptoms after starting LDN:


There is an article in today's New York Times explaining that these symptoms are actually your immune system in action. The mucus, scratchy throat, runny nose, etc., is how the body fights off infection.
These symptoms ARE NOT, ARE NOT the infection itself but the immune system's defense against the infection.


It is actually LDN at work on your behalf.

[marlène]

http://www.lowdosenaltrexone.org/

vol met allerlei testimonials en wetenschappelijke info en filmpjes

[marlène]

LDN maakt autisten siocaler


The use of LDN for children with autism spectrum disorders was previously studied in the 1990s, with researchers using from 5 to 50mg daily or every other day. In these trials, researchers were looking for opioid antagonism.

Drs. Panksepp and Shattock
Panksepp, Shattock and other researchers noted better results with low doses; studies on higher doses were more equivocal in children, and non-compliance due to the bitterness of the drug posed a problem for children who could not swallow capsules.

In private correspondence with earlier autism researchers Drs. Panksepp and Shattock, they postulated that the LDN therapeutic effect with the rebound of endogenous opioids in the brain “loosens up” the opioid social-reward systems so children who were not connecting to the many known opioid based social rewards in the environment begin to respond to those rewards.

Both these researchers emphasized the importance of positive social reactions being reinforced and enhanced substantially by social support and encouragement, helping the new behavior become part of positive behavior modification.[7]


Marchetti Study
An Italian study done in 1996 by Scifo and Marchetti attempted to correlate immunological determinations and behavioral performance in treatment with naltrexone in 10, 20, and 30mg doses in autistic children, with significant reduction of autistic symptoms noted in 7 out of 12 children.

The behavioral improvement was accompanied by alterations in the distribution of the major lymphocyte subsets, with:
significant increase in normalization of the CD4/CD8 (T1) ratio and
an inverse ratio of changes in NK cell activity to plasma beta-endorphin levels.

Bron: www.autismpedia.org/wiki/index.php?title=LDN

[greta]

bijzonder!!!

[karolien]

Weten jullie ook of die resultaten behaald door LDN blijvend zijn?
Want ik meen ergens gelezen te hebben dat iemand na enkele maanden geen effekt meer voelde?

en kan je dit middel jaren en jaren na elkaar blijven nemen?
Of kan je ermee stoppen na een tijd zonder terugval???

[marlène]

Er bestaat inderdaad bij sommige mensen een plateau-effect - dus tijdelijk geen verbetering - maar dan zet de trend zich weer in goede richting voort totdat het lichaam zijn balans heeft gevonden.

[greta]

Van een ME forum

April 4th, 2010 04:12 PM #258 darkrobot
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Junior Member

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Join Date:Jan 2010
Location:UK
Posts:27
Hi folks, I'm new to this thread but thought I'd add my experience with LDN. I have had ME/ CFS for many years, in a mild/ moderate form with lots of remissions and relapses, but it was misdiagnosed as various other things until 2 years ago, when I had a horrendous crash. That is when I got the ME/ CFS "diagnosis", and was finally signed off work despite having struggled to cope for years (my previous GP refused to believe there was anything physically wrong with me as all my NHS blood tests were normal).

The NHS offered me nothing apart from CBT. However about 9 months ago, I started a combined antibiotic protocol after a private doctor found spirochetes and micrococci in my blood. I have also been on various supplements for mitochondrial dysfunction. I have also been taking as much allicin (natural antibiotic, antiviral, antiparasitic and antifungal) as I can afford. These have all helped a lot, but I was still far from being completely well.

A few months ago I started on LDN, and the results so far have been amazing. I am now up to 3ml per day and am, dare I say it, feeling better than I have done for many years- maybe ever? I have lots of energy, have been doing exercise for fun, even some jogging. This time last year I could barely make it to the end of my street without collapsing. I was deteriorating rapidly and feared that I would soon need a carer as even getting out of bed, washed and dressed by myself was a mammoth task. If I went food shopping (there was no-one who could do it for me) I spent the rest of the week recovering from the exertion.


The biggest revelation however, has been the reduction in brain fog. I had no idea how poor my cognitive function had become until my brain started working properly again! I think everyone (including me) just assumed I was a bit thick. I have recently started an Open University course, eventually leading on to a law degree, which would have been absolutely inconceivable before. My assignments so far have gone really well, I have got excellent feedback and am getting top marks for the first time since primary school! (I was quite a clever kid, until my descent into brain fog started at about the age of 9/10).

Sorry for waffling, but I wanted to give a bit of background to provide perspective for the improvements. It is obviously dfficult to judge exactly how much is down to LDN and how much to the other meds, but I have noticed a great deal of rapid improvement since starting LDN. I don't want to count my chickens just yet, but am hoping I am finally on the road to recovery. My only real side effect was initial insomnia- however that soon wore off and I am now sleeping better than I have done in years and feel refreshed on waking rather than resembling the living dead.

[greta]

Van datzelfde forum:


I felt more cheerful and less foggy the very next morning after I started it.

I also immediately had better sleep and started remembering some dreams, which I hadn't done in decades. I now sleep more and better than I have in years, with the feeling of actually being sleepy and tired instead of burnt out exhausted and still agitated. Brain fog was immediately better, fingers more nimble while typing, better coordinated, stumbling less, walking more and farther, no more setting things down in space instead of on the counter or desk.

I continue to have all those improvements, plus incrementally better energy and stress/overstimulation tolerance. My startle response is better and I can better tolerate noise and commotion.

My partner tells me I am much easier to live with. And my libido and sexual response are much, much stonger. (Might be part of why my partner thinks I'm getting better, eh?)

The down side: I had stomachaches at first, but those have gone away. I've learned to eat some yogurt right after taking the LDN, and that drinking beer after taking the LDN gives me a stomachache, but rum and wine do not. I can drink beer in the afternoon, but I'm losing my taste for it, so rarely do.

I started getting headaches only the left side, new for me, and occasionally a migraine-like visual disturbance, on the left all but once, with only a slight headache. Those have gone away, too.

For a couple of weeks I was dizzier than I've ever been before, feeling like I was on a rocking boat deck. That's gone now. Seems like something in my head and eyes has been fixed.

Restless legs movement almost entirely gone, happens only occasionally and not for long, as I fall asleep much more quickly and usually stay asleep all night, if I don't have to get up to go to the bathroom. No more waking up and not being able to go back to sleep and feeling angry about it. Feeling a lot less angry about just about everything, in fact.

PEM seems to be somewhat better. Hard to tell as I've been watching myself, trying not to overdo. But I have done more than I should at times and haven't suffered the crash I feared. Taxi drivers are on strike here, my main method of transport, so I've had to walk more than I would like, but, so far, I've been able to handle it. There have been times that I didn't start home soon enough and so, by the time I got home, I was weepy and feeling so bad I just had to go to bed and cry a little. Hasn't happened since I started LDN.







Location:Albuquerque
Hi Everyone,

I've been "missing" for a while--not sick but busy--and LDN is one of the reasons I can manage to be "busy."

As to how soon the effects are felt, for me it was immediate--the next day. But it took several months of slowly increasing the dose to notice the "wow, I am different" effects. I have been on it now for 7 months and feel like I am still improving. I recently actually conquered a sinus infection--a problem that has been chronic for me for decades. Before my immune system would launch a brief attack and suppress the infection without clearing it. Now it seems to have actually cleared it.

It is great to hear the good stories on this forum and I wish we had wise advice for those who do not respond well. I just send my good wishes.

Sushi

[senna]

Zou DML ook LDN kennen/voorschrijven ?

[stier]

Hee Senna, daar was ik ook benieuwd naar ja. Ik krijg over 2 maanden mijn eerste behandelplan bij DML.

[marlène]

Geen enkele specialist die ik heb aangesproken tot hiertoe, kent het of het gebruik.

Ze kennen het alleen in de hoge dosis dus de 50 mg voor de drugs- en alcoholverslaafden.
Terwijl immuunziekten voldoende hebben aan 3,5 - 4,5 gram, vandaar de naam LOW DOSE.

[marlène]

http://www.fiikus.net/?ldn

I am a Finnish CFS/ME patient, medical writer and author. I was a speaker at the 2nd European LDN conference in Glasgow in April 2010, talking about my, my doctor's and some other Finns' experience with LDN in CFS/ME. I wrote a report of this conference and there are also photos.

Other LDN articles I've written are linked near the bottom of the page. I have also collected huge page of scientific references related to LDN, which could previously only be found on my Finnish LDN site.

My own medical textbook, Reviving the Broken Marionette: Treatments for CFS/ME and Fibromyalgia also features LDN among more than 250 other medications for these illnesses.
even link naar boek gemaakt admin

I do make a point to stress that LDN is the treatment I recommend most.

The new Finnish version, out from Finn Lectura in May 2010, has a foreword from professor Olli Polo, who prescribes LDN for CFS/ME and fibromyalgia in Finland.